What are SERMS?

SERMs (Selective Estrogen Receptor Modulators) - Block estrogen from acting on tissue.

Nolvadex (tamoxifen citrate)
10mg tablets = 15.2mg of tamoxifen citrate which is equivalent to 10mg of tamoxifen.
20mg tablets = 30.4mg of tamoxifen citrate which is equivalent to 20mg of tamoxifen.

Raloxifene: Raloxifene is a selective estrogen receptor modulator that produces both estrogen-agonistic effects on bone and lipid metabolism and estrogen-antagonistic effects on uterine endometrium and breast tissue.

Clomiphene Citrate (Clomid, Clomifen, Serophene): Clomid is capable of reacting with all of the tissues in the body that have estrogen receptors. It influences the way that the four hormones GnRH, FSH, LH and estradiol, relate and interrelate. It appears that Clomid fools the body into believing that the estrogen level is low. This altered feedback information causes the hypothalamus to make and release more gonadotropin releasing hormone (GnRH) which in turn causes the pituitary to make and release more FSH and LH. More follicle stimulating hormone and more luteinizing hormone should result in increased testosterone production. Like Nolvadex, Clomid is not a steroid but a triphenylethylene with anti-oestrogenic properties. The two compounds are structurally similar and their mechanism of action is also similar. The general consensus though, is that Clomid is best left as a post-cycle natural testosterone recovery product and a more appropriate anti-oestrogen found, as Clomid does not seem to be as effective in this role.

Droloxifine (experimental)

Idoxifene (experimental)

Toremifene Citrate (experimental): Less toxic than tamoxifen citrate and better on lipids and bone density. Discussions: 1 2

AIs (Aromatase Inhibitors): Aromatase is the enzyme that causes the conversion of testosterone into estradiol and androstenedione into estrone. Aromatase inhibitors lower the amount of estrogen in post-menopausal women who have hormone-receptor-positive breast cancer. The hormone estrogen delivers growth signals to the hormone receptors. With less estrogen in the body, the hormone receptors receive fewer growth signals, and cancer growth can be slowed down or stopped.

6-OXO (chemical name: 3,6,17-androstenetrione): A suicide inhibitor of aromatase. Binds to the aromatase enzyme in a permanent and irreversible manner, rendering it inactive. The result of this is an eventual diminishment of aromatase enzyme in the body and a concomitant reduction in estrogen levels. A corresponding increase in testosterone production is usually experienced as well.

Arimidex (chemical name: anastrozole): Type 2 "non-steroidal inhibitors." They also stop the activity of the aromatase enzyme, but not permanently. Arimidex is the perfect choice for when using high doses of aromatising steroids, or indeed even for moderate doses if the individual is prone to gyno. It is thought that it may be possible to lower oestrogen levels too much with Arimidex and for this reason blood tests are recommended to determine whether the dosing schedule is correct for maximum results, as it is theorised that some oestrogen presence is required to keep the androgen receptors 'open'. Arimidex has excellent binding qualities at the receptor and therefore only low doses are required. The main downside is its price; it's very expensive. Dosing: Arimidex is supplied in 1mg tablets. Usual dose is between 0.25 - 1mg per day. In most cases 0.5mg per day is sufficient.

Letrozole (Femara): An oral, anti-estrogen drug used for treating postmenopausal women with breast cancer. Letrozole prohibits the enzyme in the adrenal glands (aromatase) that produces the estrogens, estradiol and estrone. Can be taken with or without food.

Aromasin (chemical name: exemestane): Type 1 "steroidal inhibitor," which stops the activity of the aromatase enzyme forever.

Chrysin: Chrysin is a flavonoid that has been purported especially in the bodybuilding world