International clinical trials published on Wednesday confirm the hope that cheap, widely available steroid drugs can help seriously ill patients survive Covid-19, the illness caused by the coronavirus.

Based on the new evidence, the World Health Organization issued new treatment guidance, strongly recommending steroids to treat severely and critically ill patients, but not to those with mild disease.

“Clearly, now steroids are the standard of care,” said Dr. Howard C. Bauchner, the editor-in-chief of JAMA, which published five papers about the treatment.

The new studies include an analysis that pooled data from seven randomized clinical trials evaluating three steroids in more than 1,700 patients. The study concluded that each of the three drugs reduced the risk of death.

JAMA published that paper and three related studies, along with an editorial describing the research as an “important step forward in the treatment of patients with Covid-19.”

Corticosteroids should now be the first-line treatment for critically ill patients, the authors said. The only other drug shown to be effective in seriously ill patients, and only modestly at that, is remdesivir.

Steroids like dexamethasone, hydrocortisone and methylprednisolone are often used by doctors to tamp down the body’s immune system, alleviating inflammation, swelling and pain. Many Covid-19 patients die not of the virus, but of the body’s overreaction to the infection.

In June, researchers at Oxford University discovered that dexamethasone improved survival rates in severely ill patients. Researchers had hoped that other inexpensive steroids might help these patients.

The evidence had been lacking: After the Oxford researchers made their announcement, some clinical trials of steroids were halted, as doctors were loathe to withhold what appeared to be an effective treatment from study participants.

Steroids can have harmful side effects, especially in elderly patients, who make up the majority of very ill coronavirus patients. The drugs may leave patients vulnerable to other infections, may raise blood glucose levels, and may cause confusion and delirium.

In the clinical trials, only the sickest patients were treated with steroids, and it is not certain that those who are less ill will benefit or be harmed. The optimal doses and duration of treatment also need to be identified.

But over all, the scientists said, the new studies appeared to confirm the promise of this class of drugs for patients severely ill with Covid-19.

The studies “are like the second punch of a one-two punch,” said Dr. Derek C. Angus, chair of the department of critical care medicine at the University of Pittsburgh, who co-authored one of the new studies and the analysis.

“I had a big smile on my face when I saw the results,” Dr. Angus added. “This is a case of, ‘A question asked, a question answered,’ and that’s so rare.”

The analysis of pooled data found that steroids were linked with a one-third reduction in deaths among critically ill Covid-19 patients. Dexamethasone produced a 36 percent drop in deaths in 1,282 patients treated in three separate trials.

Hydrocortisone, tested in 374 patients in three trials, appeared to reduce deaths by 31 percent, and a small trial of methylprednisolone in 47 patients resulted in a 9 percent drop in deaths. The analysis was carried out by a W.H.O. working group that is making efforts to rapidly evaluate Covid-19 therapies.

Taken together, the new studies will bolster confidence in the use of steroids and address any lingering hesitancy on the part of some physicians, said Dr. Todd Rice, an associate professor of medicine and critical care physician at Vanderbilt University School of Medicine.

In new guidance, the W.H.O. warned against indiscriminate use of steroids, emphasizing that patients who are not severely ill are unlikely to benefit and may suffer side effects. Unwarranted use could deplete global supplies, depriving patients who genuinely need the medications.

The health organization started work on its guidance in June, shortly after Oxford University published a preliminary report of its findings, partnering with investigators of seven clinical trials in order to conduct a meta-analysis and provide additional evidence in the most expeditious manner, W.H.O. officials said.

They characterized the quality of the evidence in favor of steroid treatment for severely ill patients as one of “moderate certainty.”

Among the other studies published Wednesday was a Brazilian trial of 299 patients with acute respiratory distress syndrome that compared dexamethasone treatment with regular care. The steroid significantly improved outcomes, increasing the number of days patients were alive and free of mechanical ventilation.

 

Read full article at: https://www.nytimes.com/2020/09/02/health/coronavirus-steroids.html

Related Topics

WHO Endorses Steroids as Lifesaving

International clinical trials published on Wednesday confirm the hope that cheap, widely available steroid drugs can help seriously ill patients survive Covid-19, the illness caused by the coronavirus.Based on the new evidence, the World Health Organization issued new treatment guidance, strongly re ...
Steroid News

Larry Wheels: I Stopped Steroids (Video)

Larry Williams' journey to becoming "Larry Wheels," a 24-year-old social media star, power lifting prodigy, rising bodybuilder, and aspiring strongman, begins on a Caribbean island with a slim teenager lifting a pair of cinder blocks hooked to a broomstick. Williams, the only child of a single mothe ...
Bodybuilding News

Legal Steroids vs Steroids

"Legal Steroids" Do they actually work?In this article without dwelling too much into the science behind the mechanism of how Legal Steroids or Steroids actually work, I shall try to compare the both based on their safety, health and results. Let's get straight into it.What are Legal Steroids?By def ...
Steroid News

Ultimate Raw Guide on Buying Steroids

What are steroids? Where to buy steroids online? Is it safe to buy steroids online? What to expect when buying steroids online?Questions similar to the above were common but finding accurate answers to them was difficult. One had to roam through the internet for days to learn the art of buying stero ...
Steroid News

Sergio Oliva: The Myth

Name: Sergio OlivaDate of Birth: July 4, 1941Height: 5 ft 10 in (178 cm)Off-season Weight: 235 lb (107 kg)Competition Weight: 225 lb (102 kg)Arm size: 22.5″ (57.15cm)Leg size: In Inches – 28, In Meters - 0.7112, In Centimeters - 71.12Waist size: 27″ (68.58cm)Calf size: In Inches &n ...
Famous Bodybuilders

The Kali Muscle Story

Name: Kali “Muscle” KirkendallDate of Birth: 18 February 1975Height: 175 cm (5 ft 9 in)Off-season Weight: 91 kg (200lbs)Competition Weight: 84 kg (185lbs)Body Fat: 5-8%Championships: NoneBiography of Kali Muscle“Strong people don't put others down, they lift them up” – ...
Famous Bodybuilders

More on SteroidsWiki

Khabib just signed with a Russian football club

Ex-MMA star Khabib Nurmagomedov has just signed a contract with a Russian 3rd Division football club.The former lightweight MMA world champion retired a few months ago, aged just 32. It was following his last fight won in October 2020 that Khabib announced his retirement. He had subsequent ...
Combat Sports

Steroid Profile: Deca Durabolin

Overview And History Deca-Durabolin (Nandrolone Decanoate)Deca Durabolin is a very popular anabolic steroid made up of the steroidal hormone Nandrolone and the massive Decanoate ester. The Nandrolone hormone initially debuted in 1960 and was commercialized by Organon in 1962 under the marketing name ...
Steroid News

Maddox Attempts Bench Press World Record

Famous in the bodybuilding universe, Julius Maddox regularly tries to break world records, especially in the bench press.At the start of 2020, the 34-year-old athlete had pressed 354.7kg (782.6 pounds). During August in a video posted by Matt Rhodes Sport on youtube, he can be seeing moving a bar at ...
Bodybuilding News

Zane Watson Booked

Last month, a professional bodybuilder was arrested along with 20 other people during a police raid. The investigation report shows Zane Watson's name on the list of those arrested. Watson is a pro IFBB bodybuilder in the 212th division. Canadian police says that they seized the equivalent of $ ...
Bodybuilding News

Magnesium in Bodybuilding?

In general, magnesium is necessary for optimal functioning of the muscles, because if the body lacks magnesium, the permeability of the membranes to calcium, sodium and potassium increases. This phenomenon increases the excitability of nerve cells and the tendency to cause muscle cramps.On the muscu ...
Bodybuilding News

Big Ramy ramming up for Olympia 21

As the 2021 Olympia approaches, Big Ramy confirms his spot as the favourite.Mamdouh Elssbiay, an Egyptian IFBB PRO bodybuilder, more famously known by his nickname Big Ramy successfully secured the first position at Mr Olympia 2020 and intends to do a back-to-back.In a latest video posted on the soc ...
Bodybuilding News

Michal Krizo Wins Mr. Universe Pro (Video)

We recently covered Michal Krizo in an article Man with the Perfect Physique.The Slovakian athlete proved this by winning Mr. Universe Pro last Sunday. It is a meteoric success for the bodybuilder who was not very well known before.After some photos of him were shared on the networks, Michal Krizo g ...
Bodybuilding News

Jay Cutler

Name: Jay CutlerDate of Birth: August 3, 1973Height: 5’ ft 10”Off-season weight: 290 lbs.Competition weight: 260 lbs.Upper arms: 22”Chest: 58”Thighs: 30”Waist: 34”Calves: 20”Biography of Jay Cutler"NEVER GIVE UP! GREAT THINGS TAKE TIME"Let's talk about someo ...
Famous Bodybuilders

Role of Zinc in Bodybuilding

Adequate zinc intake directly affects performance and strength in training because it plays an essential role in the production of natural anabolic hormones.Research shows that having significant amounts of zinc available in the body allows for higher secretion of the 3 most important hormones i.e.t ...
Bodybuilding News

Iron Biby: Strongest Man Log Press (Video)

On September 18, 2021 during an event in Scotland, Iron Biby broke the Log Press world record.What is “Log Press”?To summarize, “Log Press” is a weightlifting feat. that requires huge amounts of strength to perform.Iron Biby's World RecordIron Biby, whose real name is Cheick ...
Strength Sports

How to add a Pharmacy/Source?

To add a pharmacy / source please visit: https://www.roidbible.com/add-sourceThe page is designed to allow you to easily add a pharmacy to our list of pharmacies. Just follow the instructions on the page, fill in captcha and submit. It only takes a few seconds to add a pharmacy to RoidBible's Databa ...
Other

Champion of France: Mathilde Fréville

Saturday June 4 in Figeac, Mathilde Fréville became French junior champion in 59 kg category. A first national title for the 20-year-old athlete.Her first contact with the sports world was Alliance Dijon Natation known for his swimming. Thanks to her father, a coach in the main swimming pool ...
Strength Sports
SteroidsWiki.com Please Login or Register to learn, share knowledge and grow.