Profile of Anavar Oxandrolone

Chemical Name: 17β-hydroxy-17α-methyl-2-oxa-5α-androstane-3-one
Molecular Weight: 306.44 g/mol
Formula: C19H30O3
Original Manufacturer: Searle Laboratories (now Pfizer Inc.)Oxandrolone.svg
Half-Life: 9 hours
Detection Time: 3 weeks
Anabolic Rating: 322 – 630  
Androgenic Rating: 24

Overview & History of Anavar Oxandrolone

Anavar is the trade name for the oral anabolic steroid Oxandrolone, which is the generic chemical name. Anavar was developed and marketed during the height of anabolic steroid research between the 1950s and the 1980s. It is the apex of the never-ending quest to discover and develop an anabolic steroid that could be considered perfect. With this being said, Anavar is perhaps the closest that science has come to developing what would be considered the perfect anabolic steroid.

 Anavar represents one of the most popular oral anabolic steroids of all time, and this is largely due to its well-tolerated nature. Anavar is without question an extremely beneficial anabolic steroid, but to appreciate its benefits, we must understand it.

Anavar is the popular brand name associated with the dihydrotestosterone-derived anabolic steroid Oxandrolone. However, in 1989 Searle would discontinue the compound; this was largely due to FDA pressure that had tightened its grip on the anabolic steroid market.

An important note; Searle also owned the licensing rights to the majority of Oxandrolone products and it remains one of the more expensive anabolic steroids on the market, including when purchased from most underground labs.

Anavar's history can be traced back to 1962 when it was known as Oxandrolone. Soon after, G.D. Searle & Co. Laboratories, which is now known as Pfizer Inc., introduced it to the prescription drug market under the brand name Anavar. Other pharmaceutical firms have used different trade and brand names for Oxandrolone. Protivar, Anatrophil, Antitriol, Lipidex, and Lonavar are some of the brand names.

Anavar was one of the pharmaceutical industry's biggest hits on the prescription market owing to a slew of medical papers demonstrating that the medicine was well tolerated by a large number of patients.

Anavar is a modified DHT (Dihydrotestosterone) derivative with several changes that affect its activity in various ways. Its C-17 alpha is alkylated to allow for oral administration, and its second carbon atom has been replaced with an oxygen atom, giving it more anabolic potential. Anavar has a minimum of 3 times the strength of Testosterone and a maximum of 6 times the strength of Testosterone, according to research.

Chemistry Behind Anavar Oxandrolone

As such, Anavar is essentially Dihydrotestosterone with a methyl group attached to the 17th carbon (known as C17 Alpha Alkylation), which is the chemical structural modification that allows the anabolic steroid to survive the first pass through the liver when ingested orally and allows the anabolic steroid to be more resistant to hepatic metabolism.

One of the methods by which this modification increases Anavar’s anabolic strength (in comparison to DHT) is believed to be an increased resistance to the enzyme 3-hydroxysteroid dehydrogenase, which is the enzyme highly abundant in muscle tissue that is responsible for the conversion of Dihydrotestosterone into a non-anabolic inactive metabolite.

Anavar is an anabolic steroid derivative/analog that belongs to the Dihydrotestosterone (DHT) class. Other anabolic steroids in the 'DHT family' include Winstrol, Primobolan, Masteron, and numerous more, all of which are derivatives of the parent anabolic steroid DHT. All of these anabolic steroids have one thing in common: they are all changed versions of DHT in some form, and so DHT might be regarded as the 'parent' hormone of these anabolic steroids.

In comparison with Testosterone, which has an anabolic: androgenic ratio of 100:100 respectively, it is easily seen that Anavar is far less androgenic and possesses a stronger anabolic strength of at least 3 times the strength of Testosterone, and studies have demonstrated anabolic strength as high as 6 times that of Testosterone with very little accompanying androgenic activity.

It can be easily seen how these characteristics make Anavar a favorable compound among athletes and bodybuilders wishing to increase athletic performance, muscle gain, and strength gain where the additional water weight gain is undesired. It is also an anabolic steroid used extensively by bodybuilders wishing to shed body fat and maintain as much muscle as possible during a caloric deficit, where once again extra water weight and possible fat retention/gain are not desired.

 In regards to its reported anabolic rating of 322 – 630, the reason why it is given this range as opposed to one solid number for its anabolic rating (such as Trenbolone’s rating of a solid 500 or Testosterone’s rating of a solid 100) is due to Anavar’s nature as an oral anabolic steroid. Some percentage will still be unfortunately lost, and therefore that is the reason why instead of a solid number, a general range is given for many anabolic steroids (mostly oral compounds for the reasons stated, as strength can vary due to liver metabolism).

Side Effects of Anavar Oxandrolone

The Oxandrolone hormone does not carry any estrogenic-related side effects. It does not aromatize and cannot lead to gynecomastia or water retention due to increases in estrogen levels.

It further carries no progestin-related activity, which again supports no estrogenic-related side effects. Due to water retention being impossible with this steroid, this will decrease the risk of high blood pressure.

Excess water retention can promote high blood pressure. Some steroids that do not aromatize can lead to high blood pressure, such as Trenbolone, but Anavar is rarely associated with this trait.

 However, most will not have an issue with these effects as the total androgenic nature remains very low. An important note; 5-alpha reductase inhibitors are often used to combat androgenic side effects brought on by the use of anabolic steroids.

However, this will not have a strong effect when using Anavar as the Oxandrolone hormone is not affected by the 5-alpha reductase enzyme. The androgenic nature, although slight, can also promote virilization symptoms in women. Thankfully the virilization rating of Anavar is extremely low; most women can supplement without falling to such effects as long as they supplement responsibly.

There will always be the issue of individual response to contend with, but the Oxandrolone hormone continues to represent the safest anabolic steroid for female use. Of the possible side effects of Anavar, the most concerning will surround cholesterol. The Oxandrolone hormone is well-known for suppressing HDL cholesterol, as well as increasing LDL cholesterol.

The Oxandrolone hormone is well-known for suppressing HDL cholesterol, as well as increasing LDL cholesterol. Performance doses may also increase LDL cholesterol by as much as 30%. The use of anabolic steroids will suppress natural testosterone production; however, the rate of suppression varies from one steroid to the next.

Anavar is one of the milder suppressive steroids on the market, but most men are typically encouraged to include exogenous testosterone in their supplementation plan. It is, however, possible to supplement with Anavar without falling into a low testosterone state; high-end performance doses will suppress total serum levels by approximately 50%, but even with a 50% reduction some men may find they’re still in a healthy range.

This will be highly dependent on the individual’s natural levels, but most men will still find exogenous testosterone therapy to be warranted. As with all anabolic steroids, once use is discontinued and all exogenous steroidal hormones have cleared the body, natural testosterone production will begin again.

Natural recovery assumes no prior low-level state, as well as no severe damage to the HPTA through improper supplementation practices. For this reason, most men are encouraged to implement a post cycle therapy (PCT) plan once all steroid use is complete. PCT plans should include a SERM such as Nolvadex or Clomid, and often benefit from the use of HCG.

Liver enzyme values will typically increase with use, however, of all C17-aa steroids Oxandrolone carries a minimal hepatic nature. Data has shown therapeutic doses may not increase liver enzyme values significantly. Performance doses are another story, but the hepatotoxic nature will still be significantly less than most C17-aa anabolic steroids. You should avoid excess alcohol consumption when using a C17-aa anabolic steroid as this will burden the liver tremendously.

Many over-the-counter medications carry a hepatotoxic nature; in some cases, greater than many anabolic steroids. You should limit your total use of Oxandrolone to 8 weeks max and should not supplement with any C17-aa steroid until again until liver enzyme values have normalized. You should incorporate a liver detoxifier into your plan during the use of Oxandrolone or any C17-aa anabolic steroid.

Cycles And Usage of Anavar Oxandrolone

Although it can perform and assist quite well in the area of achieving fat loss and physique definition, it is an excellent compound for mass gaining, strength, and bulking. Being that it is 3 – 6 times the anabolic strength of Testosterone, Anavar cycles can indeed be bulking cycles without issue. However, because Anavar does impose some strain and toxicity in the area of liver function, it cannot be utilized for the same length of time as those core injectable compounds can.

Anavar cycles can be extended to a maximum of 10 weeks at a reasonable dosage, however, due to its lower degree of liver toxicity than other oral compounds. For its use in fat loss and cutting, Anavar cycles are often shorter and utilized with compounds used for achieving similar goals.

Standard Anavar dosages for therapeutic treatment are usually between 5 and 10 mg per day, with a maximum dose of 20 mg per day. Typically, such usage will continue for 2-4 weeks, with a little rest afterward before beginning the following 2–4-week cycle. This practice will continue for as long as it is considered necessary.

A 20-30mg per day dose will give athletic enhancement for the male performance-enhancing athlete, but most will find 40-50mg per day to be significantly more effective. It is fairly unusual to take 80 mg per day, however, this will raise the chance of negative effects. The average male Anavar cycle lasts 6-8 weeks.

5-10mg per day is usually the ideal amount for a female performance-boosting athlete, regardless of the reason for use.

Only a small percentage of women will require more than 10mg each day. If more is desired and 10mg per day has been tolerated successfully, 15mg per day can be tried next time. Every increase in dose, however, raises the chance of virilization. Dosages of 20mg per day will significantly raise the risk, with doses beyond this amount almost certain virilization. Female Anavar cycles typically last 6-8 weeks.

How To Buy and Price of Anavar Oxandrolone

Anavar is a popular anabolic steroid for a variety of reasons, but it is also notorious for being one of the costliest anabolic steroids available. Individuals can acquire both pharmaceutical and underground (UGL) grade Oxandrolone on the black market, however, pricing discrepancies become an issue.

We can properly compare the market pricing of Anavar between underground and pharmaceutical quality items by using a baseline standard of 10mg pills. A box of 60 pharmaceutical-grade Anavar pills, each dosed at 10mg, can cost anywhere between $70 and $150.

Under the identical conditions (60 tablet lot, 10mg per tablet concentration), Underground Var might cost anything from $60 to $180. The type of source utilized (in-person vs. internet sources, etc.) and the exchange rates of currencies at the time of purchase can significantly alter Anavar pricing, as black-market prices are greatly influenced by them.

Purchasing Anavar online is without a doubt the most convenient method of obtaining this anabolic steroid. There appear to be an infinite number of steroid providers on the internet, and while many of them are worthless, there are plenty of reputable ones. Keep in mind, however, that purchasing Oxandrolone on the illicit market in the United States is prohibited.

Oxandrolone is a Schedule III restricted drug in the United States. To legally acquire Anavar, you'll need a prescription from a doctor, and you'll have to buy it from a drugstore. Failure to follow this legislation can have devastating repercussions. Many nations throughout the world have comparable rules, but many are significantly more liberal; familiarize yourself with the legislation in your area.

Recent Research on Anavar Oxandrolone

Coffee had a favorable influence on bioavailability and absorption in recent Portuguese research assessing the effects of Oxandrolone ingestion.

The peer-reviewed and double-blind trial were done by the Portuguese doping lab Laboratorio de Analisis de Dopagem, which gave the patients 300mg of caffeine coupled with Oxandrolone. When comparing the Oxandrolone + Caffeine group to the Oxandrolone alone group, the researchers found that plasma concentrations were higher in the Oxandrolone + Caffeine group.

The outcomes were noteworthy. There was a 1900 percent (20-fold) rise, which is rather significant. If you're using Anavar (Oxandrolone), it's recommended to combine the oral anabolic steroid with a cup of coffee, supplemental caffeine, or your pre-workout supplement.

 

 

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